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Jack Knox received the Man’s Best Friend Award from Paws in the City during their annual Top Hat & Tails event on June 18, 2011. He received the Humanitarian of the Year Award from Operation Kindness in 2005.
 
Knox has an ongoing interest in the well-being of animals, serving on the Advisory Board of Directors of the Texas Humane Legislative Network and as a member of the Advisory Committee to the City of Dallas Animal Shelter Commission. His dogs and cat are rescue animals.
 
Knox has also served on the Board of Trustees of Medical City Hospital in Dallas, Friends of Scott and White Hospital in Temple, M.D. Anderson Hospital Board of Visitors in Houston, and Board of Directors of the Metropolitan YMCA in Dallas. He is founder and president of the Fund for Sick Children, a private foundation that supplies medicine and equipment to hospitals and doctors in third-world countries.
 
Knox is general partner of Six Flags Over Texas Fund Ltd. and president of Café Pacific, Inc., which was recently recognized as the "Best Seafood Restaurant in Dallas" by D Magazine  in its 2011 issue of “The Best of Big D.” Beyond his work as a humanitarian and restaurateur, Knox is involved in ranching and was a part of the oil and gas industry for thirty years after graduation from law school. Knox also serves on the Executive Board at SMU Dedman School of Law.